Prolozone: Regenerative Injection Therapy for Pain Management

Prolozone treats knee injuries and pain

Are you relying on over the counter pain medication or worse yet, narcotic drugs to manage pain? Let us introduce you to a effective, natural and non-surgical regenerative injection therapy called Prolozone. Prolozone treats pain quickly so you can get on with your life!

Pain is caused by poor circulation to ligaments and joints. Aging induces decreased circulation and oxygen utilization. Trauma induces localized inflammation which results in acidosis and free radical production and possibly infection. To effectively decrease pain, we want to improve circulation, reduce inflammation, improve oxygen utilization, eradicate infection, and deliver nutrients to the area to break the pain cycle to prompt the body to heal and restore function. The oxidation process involved in Prolozone therapy also stimulates growth factor production to aid in accelerated pain reduction.

Prolozone is a regenerative injection technique utilizing ozone gas and a nutrient mixture containing B-vitamins, Procaine, Dextrose, Sodium Bicarbonate and Saline. The prolozone therapy allows for effective pain relief for both acute and chronic pain.

According to an article in the American Journal for Neuroradiology, May 2005 referencing prolozone, “The gas mixture can be administered as a first treatment to replace epidural steroids.”

At the Fifth International Symposium on the Application of Ozone, in April 2007 in Havana, Cuba it was concluded that Osteoarthritic conditions resistant to over the counter pain relievers such as aspirin also respond favorably to prolozone injections.

The Prolozone shot has also been declared to be as effective as surgery for herniated discs, reported by Neil Wagner in CyberRounds, online at A Toronto Team examined the results of 8000 patients in 12 different studies determining that ozone therapy was just as effective as surgery with shorter recovery and a much lower risk of complications. According to Dr. Frank Shallenberger, the value of Prolozone is that it actually corrects the pathology of the disorder, with 75% of chronic pain sufferers becoming pain free after undergoing Prolozone therapy.

Am I a good candidate for a Prolozone treatment?

Yes, if you suffer from acute or chronic pain. Prolozone specifically treats many other conditions including:

  • shoulder injuries
  • rotator cuff injury
  • degenerative hips or knees
  • neck or back pain
  • degenerative disc disease
  • plantar fasciitis
  • carpal tunnel syndrome
  • TMJ
  • sciatica
  • heel spurs
  • neuromas
  • tennis elbow
  • non-union fractures
  • sports injuries
  • painful scarring
  • ankle injuries
  • and more...

What is the difference between prolozone and prolotherapy?

Dr. Tiffany Mitchell treating an injured ankle with prolozone therapy

Prolozone utilizes ozone gas and oxygen to stimulate collagen producing substances which can reconstruct damaged or weakened connective tissue in and around joints. Prolozone is a form of non-surgical ligament reconstruction and is a permanent treatment for chronic pain.

Prolotherapy stimulates inflammation to promote growth factor factors. Prolotherapy can be very painful, Prolozone in contrast will cause little pain to no pain after treatment.

Prolozone is an excellent complement to PRP (Platelet Rich Plasma) and Liquid Allograft regenerative injection therapies. Liquid Allograft exposed to oxidation convert to cells the body needs so it can be considered an adjunctive or “Pre” Liquid Allograft treatments.

What you should expect from a Prolozone treatment:

  • Topical numbing or pre-numbing injection at injection site to minimize discomfort
  • Immediate decrease in pain
  • Soft and hard tissue regeneration
  • 60-80% resolution of pain with 3-5 treatments, response varies from one person to the next
  • Zero side effects

In short, prolozone is a highly effective option for anyone suffering with acute pain or pain of a chronic nature. Our skilled and highly attuned Naturopathic Physicians specialize in Prolozone and regenerative injection therapies.

Contact Us Now to Get Out of Pain


Bonetti M, Fontana A, Cotticelli B, Volta GD, Guindani M, Leonardi M. “Intraforaminal O (2)- O(3) versus periarticular steroidal infiltrations in lower back pain: randomized controlled study” Am J Neuroradiology. 2005 May; 26(5): 996-1000.

Fifth International Symposium on the application of Ozone, April 2007, Havana, Cuba

Neil Wagner online at

Ozone Certification Training Course by Frank Shallenberger, M.D; H.M.D
October 20-24, 2016